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mek1 2 inhibitor  (MedChemExpress)


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    MedChemExpress mek1 2 inhibitor
    Mek1 2 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 52 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mek1 2 inhibitor/product/MedChemExpress
    Average 94 stars, based on 52 article reviews
    mek1 2 inhibitor - by Bioz Stars, 2026-02
    94/100 stars

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    (A) In presence of pyruvate during CF serum-starvation, PC detyrosination increased in a dose dependent manner. (B-D) Graphs showing the impact of acetylation inhibition using GM-90257 (B) and MAPK inhibition using inhibitors PD98059 (C) and SCH772984 (D) on the detyrosination at PC level. (E-F) Graphs showing the impact of the detyrosination inhibitor LV80 on PC length (E) , number of PC-positive cells (F) and detyrosination level of PC (G) in 24h serum starved colonic fibroblasts cultures. (A, C, D, E, G) Statistical analysis: *p<0.05, **p< 0.01, ****p<0.0001 by two-tailed unpaired t-test.

    Journal: bioRxiv

    Article Title: Pyruvate promotes ciliogenesis bypassing IFT88 dependency and attenuates DSS-induced colitis

    doi: 10.64898/2025.12.17.694572

    Figure Lengend Snippet: (A) In presence of pyruvate during CF serum-starvation, PC detyrosination increased in a dose dependent manner. (B-D) Graphs showing the impact of acetylation inhibition using GM-90257 (B) and MAPK inhibition using inhibitors PD98059 (C) and SCH772984 (D) on the detyrosination at PC level. (E-F) Graphs showing the impact of the detyrosination inhibitor LV80 on PC length (E) , number of PC-positive cells (F) and detyrosination level of PC (G) in 24h serum starved colonic fibroblasts cultures. (A, C, D, E, G) Statistical analysis: *p<0.05, **p< 0.01, ****p<0.0001 by two-tailed unpaired t-test.

    Article Snippet: The MEK1/2 inhibitor PD98059 (used at 20μM), ERK1/2 inhibitor SCH772984 (used at 300nM), the inhibitor of pyruvate transport at the plasma membrane AZD3965 (used at 200nM), the microtubule acetylation inhibitor GM-90257 (used at 500nM) and the histone acetyl transferase inhibitors for E1A-associated Protein p300 (Ep300) C646 (used at 25μM) were purchased from MCE (MedChem Express, Monmouth Junction, NJ, USA).

    Techniques: Inhibition, Two Tailed Test